Sequence is a card and board game. The board displays all the cards (except for the Jacks) of two (2) standard 52-card decks, laid in a 10 x 10 pattern. The four corners are considered free spaces and count for all players equally.

Players compete to create rows, columns or diagonals of 5 connected checkers placed on the cards that the player has laid down. Two-eyed Jacks are wild, while one-eyed Jacks let an opponent's checker to be removed. The game is over when someone has reached a specified number of connections.