In Disney Villainous: Perfectly Wretched, each player takes control of one of three Disney characters; Cruella de Vil from 101 Dalmatians, Mother Gothel from Tangled, and Pete from Steamboat Willie. Each player has their own villain deck, fate deck, player board, and 3D character.

On a turn, players moves their character to a different location on their player board, takes one or more of the actions visible on that space (often by playing cards from their hand), then replenishes their hand to four cards. Cards are items, allies, effects, and conditions. You need to use your cards to fulfill your different win conditions.

One of the actions lets you choose another player, draw 2 cards from that player's fate deck, then play 1 of them on that player's board, covering two of the four action spaces on one of that player's locations. The fate deck holds heroes, items, and effects from that villain's movie, and these cards allow other players to mess with that particular villain.

Disney Villainous: Perfectly Wretched can be played on its own, and its characters can also face off against those in the Disney Villainous base game and the Disney Villainous: Wicked to the Core and Disney Villainous: Evil Comes Prepared standalone games.