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Each one of the six Colt Express: Bandits expansions allows the players to play against the game itself, which is operating under the rules of that particular expansion. A new story is told each time as every expansion creates a specific goal and new actions for the bandit played used by the game. That bandit might win, and if that happens, all the players lose. Thus you need to work as a team against this "bot", while keeping in mind that in the end, there is only one winner — the richest bandit, of course.
In the Doc expansion, players will compete to gain the respect of Doc, but not in a friendly way. When a bandit shoots or punches Doc, they will take Doc's respect card. The bandit who has this card makes all the decisions in Doc's place.
Doc uses special bullets, with each of them triggering a different effect during the current round. Doc has another specific action: the poker game. When this action card is used, all the bandits must participate and hand over one of their loot. The player with Doc's respect gies two loot to Doc and one loot to each other Bandit except one.
Doc wins the game if he is the richest bandit at the end of the game.