In Amoeba, players draw and then place tiles in order to build the biggest amoebas, then they claim those amoebas by placing one of their nuclei markers on them. Players can also reduce an opponent's score by placing one of their tiles on a completed amoeba, thereby splitting it. There are twelve unique tiles that will require strategic thinking and pattern recognition to grow the largest amoeba. The game ends after all tiles are played, and the player with the largest amoeba wins.