Qwixx: The Card Game captures the spirit of Qwixx — with players still trying to cross off numbers in four colored rows as best they can — but this game uses cards instead of dice, allowing for additional tactics and planning as you draft and play a hand of cards.

As in the original game, in Qwixx: Das Kartenspiel every player has a scoresheet with the numbers 2-12 in rows of red and yellow and the numbers 12-2 in rows of green and blue. You will want to mark off as many numbers as possible, but you can mark off a number only if it's to the right of all marked off numbers in the same row. The deck contains 44 cards, eleven in each color numbered 2-12; the back of each card shows the number but without the color. Each player begins with a hand of four cards, and four other cards are laid out face-down — that is, with the color hidden — in a row beside the remaining deck of cards.

On a turn, a player fills their hand to five cards by drawing from the four cards on display, then refills the card display from the deck. Using the number now visible on the top card of the deck, each player can pick to cross off one instance of this number in one row on her scoresheet. The active player then plays 1-3 cards from their hand, all of which must be the same color. They can cross off the numbers on these cards — but only if at most one number is missing in the series of numbers to be crossed off. For example, if the active player discards 2, 3 and 5 in blue, they can cross off these three numbers (assuming that she hasn't crossed off any blue numbers previously); if they discards 2, 3, and 6 in blue, then they can cross off the 2, the 3, the 2 and 3, or the 6.

If a player has crossed off five numbers in a color, then they can cross off the rightmost number (2 or 12) should the opportunity arise; if they do, they also crosses off a lock token in this color. If the active player can't cross off a number during their turn, they must mark a penalty box.

When a player has "locked" two colors on their scoresheet or marked off four penalty boxes, the game ends. Each player tallies their score in each color — the more numbers crossed off, the more you score — then sums these totals and subtracts any penalty points. Whoever scores the most points wins the game!

For a variant, Qwixx: The Card Game comes with eleven multicolored joker cards, also numbered 2-12, that are shuffled into the deck. A player determines the color of this card only when using it on their turn.