Qwirkle Cubes is a sequel of sorts to Qwirkle with the objective of the game being the same as before: Make rows and columns in which the tokens all match either in color or symbol in order to score points. Each time you add tokens to the playing area, you score points equal to the rows/columns that you make or add to. Close out a row by playing the sixth token in it, and you will score six bonus points in addition to whatever else you score for the turn.

In Qwirkle, the pieces have a colored symbol on one face and are otherwise blank, but in Qwirkle Cubes the tokens have six faces in the same color, with each face having one of the six different symbols. On a turn, you will:

• Roll as many cubes from your hand as you wish.
• Play cubes from your hand to make color lines and symbol lines.
• Take and roll replacement cubes.

All cubes are visible, so players can better judge their opponents' future moves – notwithstanding their rolls, mind you. The game continues until no more cubes are left in the reserve pool and one player has placed all of her cubes. This player scores a six point bonus, then the player with the most points wins the game!