Pixel Tactics is a head-to-head tactical combat game for two players. Both players have an identical deck of 25 cards, from which they draft a leader. The leader's abilities will alter vastly the strategy and playability of every other card in the deck, making the game playable in 25 different ways.

In the game, players will take turns placing cards and attacking. Every card can activate in various ways, taking on offensive capabilities in the front rows of the unit, or support powers in the back rows. Cards may also be played as orders – powerful single-time effects that can turn the tide of battle.

Play will continue until either player's leader is defeated. A usual game is best of three or five rounds.

Pixel Tactics takes place in the same world and uses many of the characters from Level 99 Games' BattleCON: War of Indines, but its game play is completely unrelated.