Spain, 1936: General Franco and his soldiers advance through the territories of Spain, giving way to a long period of civil war and repression. After the Spanish Civil War, a group of loyalists to the Republic continued the armed struggle, forming resistance groups best known as "Maquis". Hidden in the mountains, these men and women risked their lives to protect the ideals of democracy and freedom.

Fighting against them were the Army of Franco, the Armed Police, and the Civil Guard, but the Maquis perfected their guerilla warfare in France during the second World War and were determined to take back their homeland. In the head of every Maquis resonated the echo of the desire of many compatriots: Resist!

Resist! is a fast-playing, card-driven solitaire game where you take on the role of the Spanish Maquis, fighting against the Francoist regime. Over a series of rounds, you will undertake increasingly difficult missions, and completing missions earns you the points needed to win. Failing to beat missions and enemies may cause you to lose. At the end of each round, you must pick whether to end the resistance or risk it and take on another mission.

At the start of the game, you assemble a team of twelve Maquis, which are represented by a deck of cards. At the core of the game is the tension between keeping your Maquis concealed from Franco or revealing them to unlock their full potential. Unfortunately, revealed Maquis are removed from your deck, and you likely won't be able to use them for the rest of the game. While Resist! does have some minor deck-building elements, it is mostly a "deck-destruction" game in which you have to manage your deck, balancing the decision of defeating the immediate threat with trying to move on to the next mission.