Inferno is a standalone expansion for Arcadia Quest. It is 100% compatible with the original base game and adds four new Guilds: Sharks, Tigers, Crows, and Serpents. It contains new types of heroes, such as Alchemists and Gladiators.

There is a brand new branching campaign system, and the storyline revolves around the guilds descending into a fiery abyss. There are Brimstone cards that will make the terrain risky to navigate, which operate similarly to the Tombstone cards from Arcadia Quest: Beyond the Grave.

A new mechanism called "Damnation" will tempt the heroes with powerful weapons that can corrupt the characters over time or alter the behavior of nearby monsters. There are also Angels, which are allied characters for the heroes to rescue, escort or help. Working with the Angels can impact the branching campaign path system and even allow the player to recruit them for use in later missions.