The Terrifying Girl Disorder is a strange and brain-burning set-collecting card game. The deck is comprised of seven different types of cards, with each type represented by a girl with numbers 1–7 and a special power. Players begin with a hand of cards, and each round play any number of identical cards from hand, activate that girl's special power, then collect new cards, using a unique drafting mechanism.

Every player can play a certain numbered set only once per game. When the game is over, the player who has played the most cards of a certain girl "becomes" that girl. Each different girl has a completely different way of scoring points, so you need to adapt to the other player's play rapidly.